Types of Porphyria

Acute Hepatic Porphyrias (AHP)

The Acute Hepatic Porphyrias (AHP) are porphyrias where the main enzyme defects are in the liver (hepatic). They typically present with sudden attacks of severe stomach pain, among other symptoms, which last for several days; VP and HCP may also have skin symptoms of blistering after sun exposure.

• Acute Intermittent Porphyria (AIP)
• Variegate Porphyria (VP)
• Hereditary Coproporphyria (HCP)
• ALAD-Deficiency Porphyria (ADP)

Cutaneous Porphyrias

Cutaneous Erythropoietic Porphyrias
The cutaneous erythropoietic porphyrias are porphyrias that involve various skin symptoms and the main organ involved is the bone marrow. These typically present with blistering and scarring of the skin, pain, and/or redness and swelling in sun-exposed areas.

• Erythropoietic Protoporphyria (EPP) and X-Linked Porphyria (XLP)
• Congenital Erythropoietic Porphyria (CEP)

Cutaneous Hepatic Porphyrias
The cutaneous hepatic porphyrias are porphyrias that involve various skin symptoms and the main organ involved is the liver. These do not have acute symptoms like the AHPs. They typically present with blistering and scarring of the skin.

• Porphyria Cutanea Tarda (PCT)
• Hepatoerythropoietic Porphyria (HEP)